Interactions of Lamotrigine with Topiramate and First-generation Antiepileptic Drugs in the Maximal Electroshock Test in Mice: An Isobolographic Analysis
نویسندگان
چکیده
منابع مشابه
Gabapentin synergistically interacts with topiramate in the mouse maximal electroshock seizure model: an isobolographic analysis.
The anticonvulsant effects produced by topiramate (TPM) and gabapentin (GBP)--two second-generation antiepileptic drugs, in numerous fixed-ratio combinations of 8:1, 4:1, 2:1, 1:1, 1:2, 1:4 and 1:8 were examined by isobolographic analysis in the mouse maximal electroshock seizure (MES) model. Results indicate that the combinations of TPM and GBP at the fixed-ratios of 2:1, 1:1, 1:2, 1:4 and 1:8...
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Background: The development of newer classes of antiepileptic drugs has created several opportunities for the treatment of epilepsy. Aims & Objective: The present study was designed to assess the effect of amlodipine on the antiepileptic action of lamotrigine, gabapentin and topiramate in the mouse maximal electroshock-induced seizure model. Materials and Methods: 300 Adult male mice were divid...
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ژورنال
عنوان ژورنال: Epilepsia
سال: 2003
ISSN: 0013-9580,1528-1167
DOI: 10.1046/j.1528-1157.2003.10003.x